IP protection


Please provide a short description of the state-of-the-art and/or current trends in the field? How does the result fit into it?
This research project is included in the draft EU NextGene. Objective of the project is the genotyping (genome sequencing) of sheep and cattle breeds that are primordial to be extinguished, and the preparation they of genebanks (cell lines). The research group has demonstrated that first the nuclei of freeze-dried cells retain viability in response to nuclear transplantation (Loi P. et al. PLoS One. 2008, 20; 3 (8): e2978). For which the contribution to the project is the demonstration that it is possible to prepare lyophilized gene banks, then at very low operating costs in the long term and develop methods of storage at low cost, such as lyophilization, for all types of cells.



What is the problem/need/knowledge gap that the research result is responding to?  How was it addressed before?
The main application possibilities of the project are: 1) establishment of gene banks from freeze-dried animal species threatened with extinction 2) freeze-drying technology transfer to bio-banks mainly for medical, preserving the samples in liquid nitrogen (-196 ° C). Regarding point 1, in Teramo there are species of domestic animals (sheep race pagliarola; goats Teramana goat) and wild (Apennine chamois, bear Marsicano, ect.) that are disappearing. The project would therefore have immediate application outcomes of races that characterize our territory. The European Community takes into account the large banks of biological material, for their strategic importance in the biomedical field (research, stem cells, freezing of gametes for assisted reproductive medicine). Therefore, it was consists of the Bio-Molecular Research Infrastructure (BBMI), which includes more than 200 organizations in 24 Member States (http://www.bbmri.eu/). Evidence that a low-cost technique such as freeze-drying may allow reduced storage costs an enormous amount of biological samples definitely meet a lot of interest from the global market. 




What is the potential for further research?
The originality of the research results will allow to spend in the food chain, and specifically in the preservation of the biodiversity of local breeds of sheep and goat; to consider that it would be possible to maintain the same plant cell lines. 




What is the proposed method of IPR-protection? (patent, license, trademark etc.)
The protection of intellectual property rights is proposed for the product  ” Development of protocols for the lyophilization of cell lines” by publications. 





What are the steps that need to be taken in order to secure the IPR-protection? What is the cost of IPR-protection?
Presentation of the preliminary scientific results at national and international conferences; organizing courses, conferences, and maintenance of special research equipment; update software. The costs is 20.000 Euro 






What is you overall assessment of the scientific maturity of the research result?
The search began about a year. Given its nature, the search result will mature in about two years. 







Please put X as appropriate. 1 2 3 4 5
Scientific maturity x
Synergies x
State-of-the-art/innovation x
IPR-potential x




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